I think so. Groupon for one definitely has its days numbered, Facebook is not being monetised well enough at all and the mobile thing could potentially be a huge mistake. Google+ might be trashed at some point depending on what happens to Facebook (I'll be extremely surprised if it's not reinvented in another form at some point), but that will be a minor casualty compared to the others.
Pinterest is one to watch but it's not stable enough yet, and I think they'll be approached by someone wanting to buy them, possibly Microsoft (would probably have suggested Yahoo but I doubt they can afford to). It has a hell of a lot of untapped potential though.